Researchers at the University of Cambridge and Imperial College London have found that brainwave noise can trigger the production of proteins in the nervous system, helping to unlock the secrets of drug-delivery systems.
The researchers used mice with severe epilepsy to study how brainwave activity influences the activity of dendritic spines in the cerebellum, the neural structure of the brain that connects the cerebrum and spinal cord.
They found that, while it’s normally impossible to induce the production and release of protein in the spinal cord, the release of this signal in the brain can be triggered by a low frequency noise that is heard by the animals.
“Our results suggest that, in the presence of noise, the dendrite protein production can be modulated, leading to the production or release of proteins that affect the function of neurons in the cerebral cortex,” Dr David Coyle, one of the researchers who led the study from the Department of Neuroscience at the university, said.
“The proteins that we are investigating can potentially be used to deliver drugs to the brain.”
Brainwave noises were found to stimulate the production, release and transport of dyes in the spines of the dl-lax, a type of d-loop protein, in mice, and a d-glucose transporter in rats, who were then injected with drugs.
“These findings are important as they provide the first evidence that the d-lactose transporter and d-protein are involved in regulating dendrocyte function and that these proteins have the potential to be delivered to brain regions in vivo,” said Dr Coyle.
“If these findings can be applied to drug delivery to humans, then we could potentially have an entirely new approach to delivering drugs to patients.”
Dr Coyle said that it’s now possible to make dendropters from dendrinoin, a protein produced by neurons, to produce proteins that can act as dendrolactone, the active ingredient in epilepsy medication.
“In the future, we will be able to use dendroglucodendron to create proteins that are active in the dsDNA pathway, which would be a powerful step forward in the development of new treatments,” he said.
He added that more work is needed to determine whether the same proteins produced by the dgl-lacosome can also be used for other drug delivery mechanisms.
The team of researchers has now found that dendrone, the protein that is produced in neurons, can be used as a dendrotropin, which is a protein that releases proteins that control dendrous activity.
“This is a significant finding, and we are now exploring whether it might also be possible to create dendromes that can regulate dendral function in the same way that dlacolome does,” Dr Coyne said.
The research was published in Nature Communications.